| Wk | Date & Time | Away | Home | TV | ||||
|---|---|---|---|---|---|---|---|---|
| 01 | Sat Feb 18 3:00PM ET |  | Vegas Vipers 20 | @ |  | Arlington Renegades 22 | ABC, ESPN+ | Game Summary |
| 02 | Sat Feb 25 7:00PM ET |  | D.C. Defenders 18 | @ | | Vegas Vipers 6 | FX, ESPN+ | Game Summary |
| 03 | Sat Mar 4 7:00PM ET |  | Seattle Sea Dragons 30 | @ | | Vegas Vipers 26 | FX, ESPN+ | Game Summary |
| 04 | Sun Mar 12 7:00PM ET | | Vegas Vipers 18 | @ | | D.C. Defenders 32 | ESPN2, ESPN+ | Game Summary |
| 05 | Sat Mar 18 10:00PM ET |  | Orlando Guardians 32 | @ | | Vegas Vipers 35 | FX, ESPN+ | Game Summary |
| 06 | Sat Mar 25 7:00PM ET |  | St. Louis Battlehawks 29 | @ | | Vegas Vipers 6 | FX, ESPN+ | Game Summary |
| 07 | Sat Apr 1 3:00PM ET |  | San Antonio Brahmas 12 | @ | | Vegas Vipers 26 | ESPN2, ESPN+ | Game Summary |
| 08 | Sat Apr 8 1:00PM ET | | Vegas Vipers 17 | @ | | St. Louis Battlehawks 21 | ESPN, ESPN+ | Game Summary |
| 09 | Sat Apr 15 12:30PM ET | | Vegas Vipers 21 | @ |  | Houston Roughnecks 28 | ABC, ESPN+ | Game Summary |
| 10 | Sun Apr 23 7:00PM ET | | Vegas Vipers 9 | @ | | Seattle Sea Dragons 28 | ESPN2, ESPN+ | Game Summary |
